The Micro/Nano/Molecular Biotechnology Lab
The Micro/Nano/Molecular Biotechnology Lab is educationally affiliated with the Department of Biomedical Engineering (BME) and the Macromolecular Science and Engineering Program (MACRO). Our lab is physically located within the Biointerfaces Institute (BI) and is adjacent to and affiliated with the Michigan Center for Integrative Research in Critical Care (MCIRCC).
We construct organs-on-a-chip systems to dissect cell signaling pathways, understand disease physiology, test therapeutics, and perform cell-based therapies. Tunable nanofluidic systems are used to perform multi-color histone mapping of single strands of chromatin. And aqueous two phase systems (ATPS) micropatterning enables cell printing and droplet-based bioassays.
Examples of specific projects include: Microfluidic models of cancer metastasis, Lung-on-a-chip, In vitro fertilization on a chip, Phase locking analysis in GPCR signaling, and Validation of protein biomarkers of disease for development of diagnostics.